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吡喹酮衍生物′S77078、S78015、S79046和21542对小鼠血吸虫均有明显的杀死作用。S78015、S79046和21542的剂量为200～400mg/kg/d,疗程2天,对病鼠的减虫率分别为22.5～53.9％、27.6％和32.8～66.9％;S77078 200～600mg/kg/d,疗程1～2天的减虫率为60.1～97.3％,与吡喹酮的83.6～95.6％的相近似。当S77078每天总剂量为30～60mg/Kg、疗程1～2天,对病兔和病犬的减虫率分别为18.3～40.8％和53.7～80.4％,均较吡喹酮的30～60mg/kg×1天的97.1～97.3％和89.7～98.5％的为低。
Praziquantel derivatives S77078, S78015, S79046 and 21542 have a significant killing effect on mice Schistosoma japonicum. The dose of S78015, S79046 and 21542 was 200-400mg / kg / d for 2 days. The worm reduction rates of the mice were 22.5-53.9%, 27.6% and 32.8-66.9% The worm reduction rates of 1 ~ 2 days after treatment ranged from 60.1% to 97.3%, similar to that of praziquantel from 83.6% to 95.6%. When the total daily dose of S77078 was 30 ~ 60mg / Kg for 1 ~ 2 days, the worm reduction rates of sick rabbits and sick dogs were 18.3 ~ 40.8% and 53.7 ~ 80.4%, respectively, which were 30 ~ 60mg / kg 97.1-97.3% for 1 day and 89.7-98.5% for 1 day.