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目的 研究未足月子痫前期(PE)经硫酸镁治疗后随机尿蛋白与尿肌酐比值(Upro/Ucr)和外周血胱抑素C(CysC)水平的变化.探讨未足月PE应用硫酸镁治疗的临床效果和安全性.方法 选取2013年5月-2016年1月上海市长宁区妇幼保健院确诊治疗的未足月PE患者136例纳入研究组(轻度子痫前期75例,重度子痫前期61例),选择同期住院的80例健康孕妇作为对照组.所有患者于治疗前测量随机Upro/Ucr及外周血CysC水平,研究组给予硫酸镁治疗后再次测定其随机Upro/Ucr及外周血CysC水平,并分析应用硫酸镁治疗的临床效果和安全性.结果 经硫酸镁治疗前,研究组未足月PE患者的随机Upro/Ucr和CysC水平高于对照组,重度未足月PE患者的随机Upro/Ucr和CysC水平高于轻度未足月PE患者,差异均有统计学意义(P＜0.05).经硫酸镁治疗后,重度未足月PE患者的随机Upro/Ucr和CysC水平较治疗前明显下降(P＜0.05).轻度未足月PE患者的剖宫产率、产后出血、新生儿阿氏评分等较对照组差异无统计学意义(P＞0.05).重度未足月PE患者的临床疗效和妊娠结局有显著改善.研究组未足月PE患者在治疗过程中无药物过量和明显不良反应发生.结论 硫酸镁能够明显降低重度未足月PE患者的随机Upro/Ucr和CysC水平,改善肾功能及临床疗效和妊娠结局,且无明显不良反应发生.“,”Objective To research the changes of random urine protein/urine creatinine ratio (Upro/Ucr) and cystatin C levels in peripheral blood after treatment with magnesium sulfate in preterm preeclampsia patients,explore the clinical effect and security of magnesiun sulfate.Methods A total of 136 preterm preeclampsia patients (study group) diagnosed and treated in the hospital from May 2013 to January 2016 were selected and divided into mild preeclampsia gronp (75 patients) and severe preeclampsia group (61 patients),eighty healthy pregnant women during the same period were selected as control group.Random Upro/Ucr and cystatin C levels in peripheral blood were measured before treatment among all the patients.The patients in study group were treated with magnesium sulfate,then random Upro/Ucr and cystatin C levels in peripheral blood were measured again,the clinical effect and security of magnesium sulfate were analyzed.Results Before treatment,random Upro/Ucr and cystatin C levels in peripheral blood in study group were higher than those in control group,random Upro/Ucr and cystatin C levels in peripheral blood in severe preeclampsia group were higher than those in mild preeclampsia group,there were statistically significant differences (P＜0.05).After treatment,random Upro/Ucr and cystatin C levels in peripheral blood in severe preeclampsia group were statistically significantly lower than those before treatment (P＜0.05).There was no statistically significant difference in cesarean section rate,postpartum hemorrhage,and neonatal Apgar score between mild preeclampsia group and control group (P＞0.05).The clinical effect and pregnancy outcome of severe preeclampsia patients were improved significantly.No drug overdose and adverse reactions occurred during the treatment course in study group.Conclusion Magnesium sulfate can significantly reduce random Upro/Ucr and cystatin C levels in peripheral blood and improve kidney function,clinical curative effect,and pregnancy outcome of preterm severe preeclampsia patients,and no adverse reactions occur.