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目的 了解锦州地区T1期妊娠妇女特异性甲状腺功能水平.方法 按照美国国家生化研究院推荐的标准,对2014年3月-2016年4月在锦州医科大学附属第三医院妇产科门诊就诊的T1期妊娠孕妇208例(市区121例,周边县区87例)设为T1组,健康体检中心体检的25～ 35岁151例妇女设为对照组,对两组妇女进行甲状腺功能以及甲状腺抗体的检查.仪器为Abbott公司提供的i-1000全自动化学发光免疫分析仪以及配套定标液、质控液、检测试剂等.结果 对照组与T1期妊娠妇女抗甲状腺抗体(ATA)阳性率以及甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)水平比较,差异无统计学意义(P＞0.05).对照组与T1期妊娠妇女促甲状腺激素(TSH)、血清游离甲状腺素(FT4)结果比较,差异有统计学意义(P＜0.05).T1期妊娠妇女TSH参考值范围0.10～3.72 mIU/L,FT4参考值范围0.59 ～ 1.75 pg/ml.结论 T1期妊娠妇女甲状腺功能指标与非孕期有较大差异,应建立妊娠期参考值范围,尤其在基层医院以及乡村育龄妇女中普及甲状腺功能的相关知识和检查非常必要.“,”Objective To understand the levels of specific thyroid function among pregnant women at T1 phase in Jinzhou region.Methods According to the standards recommended by American National Institute of Biochemistry,208 pregnant women at T1 phase were selected from the hospital from March 2014 to April 2016 as T1 group,121 urban pregnant women and 87 pregnant women from surrounding counties were included.A total of 150 women aged 25-35 years old receiving healthy physical examination in the hospital were selected as control group.Thyroid function and thyroid antibodies of women in the two groups were detected,the instrument included i-1000 full-automatic chemiluminescence immune analyzer and matched calibration solution,quality control liquid,and test reagents provided by Abbott Company.Results There was no statistically significant difference in the positive rate of antithyroid antibody and the levels of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) between the two groups (P＞0.05).There were statistically significant differences in the levels of serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) between the two groups (P＜0.05).Among the pregnant women at T1 phase,TSH reference ranged from 0.10 mIU/L to 3.72 mIU/L,FT4 reference ranged from 0.59 ml to 1.75 pg/ml.Conclusion The indexes of thyroid function among the pregnant women at T1 phase are different from non-pregnant women,reference range during pregnancy should be established,especially among the women of childbearing age in rural grass-roots hospitals,popularization of related knowledge and exmination of thyroid function is very necessary.