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目的探究PCT(血清降钙素原)与CRP(C反应蛋白)在诊断感染性疾病中的价值。方法选取郸城县中医院2014年12月—2015年12月收治的110例感染性疾病患者,根据患者临床表现、病史、辅助检查及体征进行诊断,分为病毒感染组(n=35)与细菌感染组(n=75);根据感染程度将细菌感染组分为局部感染组(n=49)与重症感染组(n=26)。应用免疫比浊法及免疫荧光法分别检测其PCT与CRP水平。结果重症及局部感染组患者血清CRP、PCT水平明显高于病毒感染组,差异有统计学意义(P<0.05);重症感染组患者血清CRP水平与局部感染组相比,差异无统计学意义(P>0.05),血清PCT水平明显高于局部感染组,差异有统计学意义(P<0.05);PCT检测灵敏性、特异度与准确性均明显高于CRP,差异有统计学意义(P<0.05)。结论 CRP与PCR均可作为感染性疾病诊断指标,但PCT相较于CRP灵敏性、特异度与准确性更高。
Objective To investigate the value of PCT (serum procalcitonin) and CRP (C-reactive protein) in the diagnosis of infectious diseases. Methods One hundred and seventy patients with infectious diseases were selected from Dancheng Hospital of Traditional Chinese Medicine from December 2014 to December 2015. The patients were divided into three groups according to their clinical manifestations, medical history, laboratory examinations and signs. Bacterial infection group (n = 75). According to the degree of infection, bacterial infection was divided into local infection group (n = 49) and severe infection group (n = 26). The levels of PCT and CRP were detected by immunoturbidimetry and immunofluorescence. Results Serum levels of CRP and PCT in severe and local infection group were significantly higher than those in viral infection group (P <0.05). Serum CRP levels in severe infection group were not significantly different from those in local infection group (P < P> 0.05). The serum PCT level was significantly higher than that of the local infection group (P <0.05). The sensitivity, specificity and accuracy of PCT test were significantly higher than those of CRP (P < 0.05). Conclusion Both CRP and PCR can be used as diagnostic indicators of infectious diseases, but PCT has higher sensitivity and specificity and accuracy than CRP.