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目的探讨羊水细胞核型分析在高龄孕妇产前诊断中的必要性。方法对799例孕16~+~25~+w高龄孕妇进行羊膜腔穿刺抽取羊水细胞进行培养,制备染色体并分析染色体核型。结果 799例高龄孕妇羊水细胞核型分析,共检出异常核型41例,异常发生率为51.31‰(41/799),其中1 7例为染色体非整倍体(包括嵌合体),发生率为21.28‰(17/799),24例为染色体结构异常(包括嵌合体),发生率为30.04‰(24/799)。按年龄35~37岁,38~40岁,≥41岁分为3组,每组胎儿染色体异常发生率分别为52.34‰(19/363),50.72‰(14/276),50.00‰(8/160),差异无统计学意义,P>0.05。结论高龄可单独作为产前诊断指征,羊水细胞染色体核型分析高龄孕妇产前诊断是必要的。
Objective To investigate the necessity of amniotic fluid cell karyotype analysis in prenatal diagnosis of advanced pregnant women. Methods A total of 799 pregnant women aged 16 ~ + ~ 25 ~ + w were subjected to amniocentesis by amniocentesis to culture amniotic fluid cells. Chromosomes were prepared and their karyotypes were analyzed. Results The karyotype analysis of amniotic fluid in 799 pregnant women showed that there were 41 abnormal karyotypes (51.31%) (41/799), of which 17 were chromosomal aneuploidy (including chimeras), the incidence rate was 21.28 ‰ (17/799), 24 cases of chromosome abnormalities (including chimeras), the incidence was 30.04 ‰ (24/799). The incidence of fetal chromosomal abnormalities in each group was 52.34 ‰ (19/363), 50.72 ‰ (14/276), 50.00 ‰ (8 / 160), the difference was not statistically significant, P> 0.05. Conclusion Older age can be used alone as an indicator of prenatal diagnosis, and amniotic fluid cell karyotype analysis of prenatal diagnosis of pregnant women is necessary.