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目的探讨5项炎症指标检测在慢性阻塞性肺疾病(COPD)急性加重期诊治中的应用价值及动态变化。方法本院2012年3月~2013年3月的COPD急性加重期患者58例,分别于入院当天、治疗10 d后、出院6个月时抽取空腹静脉血检测5项炎性指标,将检测指标进行各组间相互比较,并与稳定期患者进行比较、分析。结果 COPD急性加重患者入院当天的外周静脉血中5项炎症指标与治疗十天组、出院6个月组及COPD稳定组的比较,差异有统计学意义(P<0.05);治疗10 d组与出院6个月组及COPD稳定组的比较显示PCT与CRP两项指标,差异无统计学意义(P>0.05),而TNF-a、IL-6、IL-8三项指标差异有统计学意义(P<0.05)。出院6个月组与COPD稳定组比较,差异无统计学意义(P>0.05)。结论血清5项炎症指标均参与了急性期COPD的发病过程,联合多项感染指标同时检测,可以敏感地反映急性期COPD患者感染及炎症反应的转归,并有利于长期随诊。
Objective To investigate the diagnostic value and dynamic changes of 5 inflammatory markers in diagnosis and treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 58 cases of acute exacerbation of COPD from March 2012 to March 2013 in our hospital were collected on the day of admission, after 10 days of treatment and at 6 months after discharge. Fasting venous blood was collected for detecting 5 inflammatory indexes, Compare each group with each other, and compared with stable patients, analysis. Results There were significant differences in the 5 inflammatory markers in the peripheral venous blood on the day of admission as compared with the 10-day treatment group, the 6-month discharge group and the stable COPD group (P <0.05) The comparison of PCT and CRP between the 6-month discharge group and the stable COPD group showed no significant difference (P> 0.05), but there were significant differences among the three indexes of TNF-a, IL-6 and IL- (P <0.05). There was no significant difference between the 6-month discharge group and the stable COPD group (P> 0.05). Conclusions Serum 5 inflammatory markers are involved in the pathogenesis of acute COPD. Combined with multiple indices of infection, they can reflect the prognosis of acute and chronic COPD patients’ infections and inflammatory reactions and be helpful for long-term follow-up.