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采用合成内标准定量反转PCR技术测定正常人子宫肌层、未用药物治疗子宫肌瘤和用促性腺激素释放激素类似物(GnRH_A)治疗子宫肌瘤三种标本中表皮生长因子(EGF)的mRNA的含量。其目的是验证EGF在子宫肌瘤增长中起重要作用,甾体激素对其具有调节作用的假说。 本研究观察28例年龄在35～53岁(平均年龄42.0岁)妇女,3个月以内未服用激素类药物。10例妇女为对照组,因其它原因而行子宫全切术。10例子宫肌瘤患者未服用GnRH_A治疗行子宫全切术。8例子宫肌瘤患者在手术以前用nafarelin acetate(一种
The internal standard quantitative reverse PCR was used to detect the myometrium of normal human uterine fibroids, and the untreated uterine fibroids were treated with GnRH_A (GnRH_A) for the treatment of three types of uterine fibroids, including epidermal growth factor (EGF) mRNA content. Its purpose is to verify the hypothesis that EGF plays an important role in the growth of uterine fibroids and that steroid hormones have a regulatory role. In this study, 28 women aged 35-53 years (mean age 42.0 years) were observed, and no hormones were taken within 3 months. 10 cases of women as control group, due to other reasons, hysterectomy. 10 cases of uterine fibroids did not take GnRH_A treatment of hysterectomy. 8 cases of uterine fibroids patients before surgery with nafarelin acetate (a