Review：BRCA1/2 associated hereditary breast cancer

• 作 者: Li-song TENG Yi ZHENG Hao-hao
• 机 构: CancerCenter
• 出 处: 浙江大学学报：B卷英文版
• 发表日期: 2008年2期
• 关键词: BRCA1 BRCA2 乳腺癌 症状 BRCA1 BRCA2 Hereditary breast cancer
• 基金项目: Project supported by the National Natural Science Foundation of China （No. 30772510） and the Joint Program of Ministry of Health and Zhejiang provincal Government of China （No. WKJ2006-2-008）

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on