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AIM:To study the therapeutic effects of zhaoyangwan(ZYW) on chronic hepatitis B and hepatic cirrhosis and theanti-virus,anti-fibrosis and immunoregulatory mechanismsof ZYW.METHODS:Fifty cases of chronic hepatitis B and posthepaticcirrhosis with positive serum HBsAg,HBeAg,anti-Hbc andHBV-DNA were divided randomly and single-blindly intothe treatment group (treated with ZYW) and the controlgroup (treated with interferon).After 3 month treatment,the effects of the treatment group and the control groupwere evaluated.RESULTS:The serum ALT normalization was 83.3%(30/36)in the treatment group and 85.7%(12/14) in the controlgroup,with no significant difference (X~2=0.043,P>0.05).After the course,the negative expression rates of the serumHBV-DNA and HBeAg were 44.4%(16/36) and 50%(18/36)in the treatment group,and 50%(7/14) and 50%(7/14) inthe control group,respectively,with no significant difference(X~2=0.125,X~2=0.00,both P>0.05).Negative HBsAg andpositive HBsAb appeared in 4 cases of the treatment groupand 1 case of the control group.Serum anti-HBc turnednegative in 6 cases of the treatment group and 1 case ofthe control group,respectively.After the ZYW treatment,serum CD_3~+,CD_4~+,CD_8~+,CD_4~+/CD_8~+ and NK cell activationwere significantly increased.Only serum CD_3~+ and NK cellactivation were significantly increased in the control groupwith a significant difference between the two groups.Theserum C_4,C_(1q),C_3,B and C_9 were significantly increased inthe treatment group.In the control group only the serumwas increased.The concentration of serum interferon hadno change after treatment with ZYW,while it was significantlyincreased in the control group after treatment with interferon.The ultrastructure of the liver restored,which helped effectivelyto reduce the degeneration and necrosis of hepatic cells,infiltration of inflammatory cells and hepatic cirrhosis.CONCLUSION:ZYW is a pure Chinese herbal medicine.Itcan exert potent therapeutic effects on chronic hepatitis Band posthepatic cirrhosis.ZYW has similar therapeutic effectsto those of interferon.It is cheap and easily administeredwith no obvious side-effects.It can be widely used in clinicalpractice.
AIM: To study the therapeutic effects of zhaoyangwan (ZYW) on chronic hepatitis B and hepatic cirrhosis and the anti-virus, anti-fibrosis and immunoregulatory mechanisms of ZYW. METHODS: Fifty cases of chronic hepatitis B and posthepaticcirrhosis with positive serum HBsAg, HBeAg, anti -Hbc and HBV-DNA were divided randomly and single-blindly intothe treatment group (treated with ZYW) and the controlgroup (treated with interferon). After 3 month treatment, the effects of the treatment group and the control groupwere evaluated.RESULTS: The serum ALT normalization was 83.3% (30/36) in the treatment group and 85.7% (12/14) in the controlgroup with no significant difference (X ~ 2 = 0.043, P> 0.05). After the course, the negative expression rates of the serum HBV DNA and HBeAg were 44.4% (16/36) and 50% (18/36) in the treatment group, and 50% (7/14) and 50% (7/14) with no significant difference (X ~ 2 = 0.125, X ~ 2 = 0.00, both P> 0.05) .Native HBsAg and positive HBsAb were found in 4 cases of the trea tment group and 1 case of the control group. Serum anti-HBc turned negative in 6 cases of the treatment group and 1 case of the control group, respectively. After the ZYW treatment, serum CD_3 ~ +, CD_4 ~ +, CD_8 ~ +, CD_4 ~ + CD_8 ~ + NK cell activation significantly increased in the control group with a significant difference between the two groups.Theserum C_4, C_ (1q), C_3, B and C_9 were significantly increased increased inthe treatment group. the control group only the serum was increased. the concentration of serum interferon hadno change after treatment with ZYW, while it was significantly increased in the control group after treatment with interferon. The ultrastructure of the liver restored, which has effectively effectively reduce the degeneration and necrosis of hepatic cells, infiltration of inflammatory cells and hepatic cirrhosis. CONCLUSION: ZYW is a pure Chinese herbal medicine. Itcan exert potent therapeutic effects on chronic hepatitis BanIt is widely used in clinical practice.