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作者研究了14例大细胞淋巴细胞瘤。男8例,女6例,发病年龄为14～72岁,平均年龄40岁。其中8例皮疹分布在头、颈部,6例在背部。9例呈多发性损害,5例为单个皮疹,部分病例原发损害部位常有新发皮疹。患者皮损经放疗和外科治疗,2例颊部单个皮疹内注射皮质类固醇反应良好。经4～31年随访,13例患者健在,无系统性淋巴瘤发生,1例死于肺炎及肾功能衰竭。作者复习了14例患者的23份皮肤活检切片,发现多次活检显示不同的组织学表现:血管周围淋巴细胞浸润、典型的淋巴细胞瘤,结节状混合性淋巴样细胞浸润或弥散性淋巴样细胞浸润。低倍镜下大细胞团块中可见大的、淡染的细胞,时常有核分裂,周围有深染的小淋巴细胞呈
The authors studied 14 cases of large cell lymphoma. There were 8 males and 6 females. The age of onset was 14 to 72 years and the average age was 40 years. Eight of these cases had rashes on the head and neck and 6 on the back. Nine patients had multiple lesions, 5 had a single skin rash, and some patients had new skin rashes at the site of primary damage. The patient’s skin lesions were treated by radiotherapy and surgery, and 2 cases of cortical steroids in the buccal single skin rash had a good response. After 4 to 31 years of follow-up, 13 patients were alive, no systemic lymphoma occurred, and 1 patient died of pneumonia and renal failure. The authors reviewed 23 skin biopsy specimens from 14 patients and found multiple biopsies with different histological findings: perivascular lymphocyte infiltration, typical lymphoma, nodular mixed lymphoid cell infiltration or diffuse lymphoid Cell infiltration. Large, lightly stained cells can be seen in large cell clumps under low magnification, with frequent mitoses, and small lymphocytes surrounded by deep staining.