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目的探讨胰岛素样生长因子结合蛋白(IGFBP)基因与胰腺癌的相关性。方法复习近年相关的国内外文献,从胰腺癌的相关基因、IGFBP相关的肿瘤及IGFBP与胰腺癌相关性的研究等方面总结前人研究成果。结果大多数研究提示IGFBP能通过IGF依赖通路抑制肿瘤细胞的功能,但目前对IGFBP基因缺失或突变以及调控机理尚不清楚。结论 IGFBP与肿瘤密切相关,但其对胰腺癌的具体影响及其机理尚无定论,要想通过内源性的IGFBP基因水平改变来影响细胞的分化程度、调控肿瘤的生长和转移概率,还需要进一步的研究。
Objective To investigate the relationship between insulin-like growth factor binding protein (IGFBP) gene and pancreatic cancer. Methods To review the relevant literature at home and abroad in recent years and summarize the results of previous studies on the related genes of pancreatic cancer, IGFBP-related tumors and the relationship between IGFBP and pancreatic cancer. Results Most studies suggest that IGFBP can inhibit the function of tumor cells through IGF-dependent pathway. However, the mechanism of IGFBP gene deletion or mutation and its regulation is not clear yet. Conclusion IGFBP is closely related to the tumor, but its specific effect on pancreatic cancer and its mechanism are not conclusive. To change the level of endogenous IGFBP gene to affect the degree of cell differentiation and regulate the probability of tumor growth and metastasis, Further research