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鉴于维A类的生物活性与癌的化学预防有着密切的关系,因而,近年来在这方面的研究有迅速的发展,合成了大量维 A 类新的衍生物,,并研究了与防癌有关的构效关系。维 A 类的防癌作用可能是多方面的。例如抗促癌作用,能阻断外源或内源致癌物的危害;促进细胞分化,使转化或癌变的细胞分化为正常细胞;通过细胞维 A 类结合蛋白将摄入细胞的维 A 类转移入核,与基因特异效应点结合;由于干扰转录影响基因表现对细胞膜的作用,使转化细胞恢复正常形态、粘性和接触抑制;增强抗肿瘤免疫,是维 A 类抗肿瘤作用的一个重要方面。
In view of the close relationship between the biological activity of dimension A and the chemoprevention of cancer, there has been rapid development in recent years in this field and a large number of new derivatives of class A have been synthesized. The structure-effectiveness relationship. Victoria A class of anti-cancer effect may be many. Such as anti-cancer effect, can block the endogenous or endogenous carcinogens harm; promote cell differentiation, transformation or carcinogenesis of cells into normal cells; through the cell dimensional A class of binding proteins into the cells into the A-type transfer Into the nucleus, combined with the gene-specific effect point; Because interference with transcriptional effects of gene expression on the cell membrane, so that transformed cells to restore normal morphology, viscosity and contact inhibition; enhance anti-tumor immunity, is a dimension of anti-tumor effect of an important aspect.