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对杭州市区0～4岁儿童进行了CMV及抗体检测,1297名中CMV阳性48名(3.70％),各年龄组阳性率高低不一;IgM、IgG、IgA抗体阳性率分别为0.69％、0.77％、2.00％。男性儿童CMV阳性率为2.89％,女性儿童阳性率为4.73％,两者差异无显著性(P>0.05)。健康儿童与患内科疾病的儿童配对分析表明,患病儿童CMV阳性率明显高于健康儿童(P<0.01)。PCR具有较高的敏感性及特异性,能检出血清学方法阴性的CMV感染,且方法简便、快速,适于临床推广应用。
The detection of CMV and antibody in 0 ~ 4 years old children in Hangzhou city was carried out. The positive rate of CMV in 1297 patients was 48 (3.70%), the positive rates of IgM, IgG and IgA were 0.69% 0.77%, 2.00%. The positive rate of CMV in male children was 2.89%, while the positive rate of female children was 4.73%. There was no significant difference between the two (P> 0.05). The paired analysis of healthy children and children with medical diseases showed that the positive rate of CMV in sick children was significantly higher than that in healthy children (P <0.01). PCR has high sensitivity and specificity, can detect serological negative CMV infection, and the method is simple and rapid, suitable for clinical application.