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类风湿关节炎(RA)是一种致畸性自身免疫性疾病。近年发现抗环瓜氨酸肽抗体是RA新的血清学标志物。A-CCP抗体对RA具有较高的敏感性和特异性,可以用于RA的早期诊断;并且联合其他因子可以提高RA的早期诊断率;A-CCP抗体的出现与骨侵蚀性关节损害有相关性并提示转归不良;在与关节外受累情况的相关性的探讨中有所分歧;A-CCP抗体对未分化关节病的有预测作用,对老年类风湿的早期诊断有较好的敏感性和特异性。
Rheumatoid arthritis (RA) is a teratogenic autoimmune disease. In recent years, anti-cyclic citrullinated peptide antibody was found to be a new serological marker of RA. A-CCP antibody has high sensitivity and specificity for RA, which can be used for the early diagnosis of RA. Combined with other factors, the A-CCP antibody can improve the early diagnosis rate of RA. The appearance of A-CCP antibody is related to the erosive joint damage Sex and prompted negative outcomes; differences in the relationship with the involvement of extra-articular disagreements; A-CCP antibodies on the prediction of undifferentiated joint disease, early diagnosis of senile rheumatoid have a better sensitivity And specificity.