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目的 探讨血清胆红素及非高密度脂蛋白胆固醇 (non -HDL -C)水平与急性脑梗死 (ACI)的关系。方法 对 1 0 6例ACI患者的血清胆红素、non -HDL -C等指标进行检测 ,并与 1 1 4例健康对照者进行比较。结果 ACI患者血清总胆红素 (TBIL)、直接胆红素(DBIL)、间接胆红素 (IBIL)、高密度脂蛋白胆固醇 (HDL -C)较对照组低 ,低密度脂蛋白胆固醇 (LDL -C)、non -HDL -C较对照组高(P <0 .0 0 1 ) ,胆固醇、甘油三酯二组差异无统计学意义 (P >0 .0 5)。男性患者血清TBIL、DBIL、IBIL较对照组低 (P <0 .0 5或 0 .0 0 1 ) ,DBIL/IBIL比值二组差异无统计学意义 (P >0 .0 5) ;而女性患者血清TBIL、IBIL较对照组低 (P <0 .0 5或 0 .0 1 ) ,DBIL/IBIL比值较对照组高 (P <0 .0 5) ,DBIL二组差异无统计学意义 (P >0 .0 5)。直线相关分析显示 ,ACI患者血清TBIL水平与年龄、胆固醇、甘油三酯、HDL -C、LDL -C、non -HDL -C水平无明显相关性 (P >0 .0 5) ,non -HDL -C与胆固醇、甘油三酯、LDL -C呈正相关 (P <0 .0 5或 0 .0 1 ) ,与HDL -C无明显相关性 (P >0 .0 5)。结论 血清TBIL降低可作为ACI相对独立的危险因素 ,non -HDL -C增高与ACI关系密切
Objective To investigate the relationship between serum bilirubin and non-HDL-C and acute cerebral infarction (ACI). Methods Serum bilirubin, non-HDL-C and other indexes of 106 ACI patients were detected and compared with 114 healthy controls. Results Serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL) and high density lipoprotein cholesterol (HDL-C) in ACI patients were lower than those in the control group, while low density lipoprotein cholesterol -C), non-HDL-C was higher than the control group (P <0.001), cholesterol and triglyceride was no significant difference between the two groups (P> 0.05). The serum levels of TBIL, DBIL and IBIL in male patients were lower than those in control group (P <0.05 or 0.0100), and there was no significant difference in DBIL / IBIL ratio between the two groups (P> 0.05) The serum TBIL and IBIL were lower than the control group (P <0.05 or 0.01), the ratio of DBIL / IBIL was higher than that of the control group (P <0.05), and there was no significant difference between the two groups (P> 0 .0 5). The linear correlation analysis showed that there was no significant correlation between serum TBIL levels and age, cholesterol, triglyceride, HDL-C, LDL-C and non-HDL-C in patients with ACI (P> 0.05) C was positively correlated with cholesterol, triglyceride and LDL-C (P <0.05 or 0.01), but not with HDL-C (P> 0.05). Conclusions The decrease of serum TBIL can be regarded as a relatively independent risk factor of ACI. The increase of non-HDL-C is closely related to ACI