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目的观察改性几丁质生物胶治疗带状疱疹的临床疗效。方法随机选取病程3~5d的带状疱疹早期患者40例,其中对照组患者12例,给予静滴喷昔洛韦、口服甲钴胺片、外用重组人干扰素α-2b软膏治疗。观察组患者28例,给予静滴喷昔洛韦、口服甲钴胺片、外用重组人干扰素α-2b软膏和改性几丁质生物胶治疗。结果两组患者治疗5d后均无完全治愈的患者,其中观察组有效率为50.00%;对照组有效率为66.67%;治疗10d后观察组与对照组有效率均为100.00%。治疗5d和10d后两组疗效差异均无统计学意义(P均>0.05)。结论改性几丁质生物胶对缩短带状疱疹患者的病程无显著性作用。
Objective To observe the clinical efficacy of modified chitin bio-adhesive in the treatment of shingles. Methods Forty patients with shingles were enrolled in the study. The patients in the control group were treated with penciclovir intravenously, mecobalamine orally and externally with recombinant interferon alfa-2b ointment. 28 patients in the observation group were given intravenous penciclovir, oral mecobalamin tablets, topical recombinant interferon alfa-2b ointment and modified chitin bio-adhesive. Results There was no complete cure in both groups after 5 days. The effective rate was 50.00% in the observation group and 66.67% in the control group. The effective rates of the observation group and the control group were 100.00% after 10 days of treatment. There was no significant difference in the curative effect between the two groups after 5 and 10 days of treatment (all P> 0.05). Conclusion Modified chitin bio-gel has no significant effect on the course of shortening the incidence of shingles.