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硝苯啶是一种口服吸收快而完全的钙阻断剂,但遇光时易发生光化学氧化而失效,尤其在水溶液中对光更敏感.本文主要研究硝苯啶在不同有机溶剂中及其在有抗氧剂存在下的稳定性.硝苯啶为美国Pfizer公司提供,贮存液用95%乙醇配成0.01mol/L,置于琥珀色玻璃瓶,用铝箔包封后置暗室保存.实验时取贮存液稀释至所需浓度.以不同浓度的亚硫酸氢钠磷酸盐缓冲液为对照液.为了测定抗氧剂亚硫酸氢钠对硝苯啶光分解的影响,在照
Nifedipine is an orally absorbed fast and complete calcium blockers, but when exposed to light prone to photochemical oxidation and failure, especially in aqueous solution is more sensitive to light.This paper mainly studies nifedipine in different organic solvents and its In the presence of antioxidants in the presence of nifedipine for the United States Pfizer company, the stock solution with 95% ethanol dubbed 0.01mol / L, placed in amber glass bottles, sealed with aluminum foil placed in a dark room to save the experiment When the stock solution was diluted to the desired concentration in different concentrations of sodium bisulfite phosphate buffer solution as a control solution in order to determine the antioxidant sodium bisulfite photodegradation of nimone,