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氨鲁米特(AG)是绝经后转移性乳腺癌,激素治疗的有效药物.AG抑制胆固醇侧链裂解酶和C-21,C-11,C-18甾体羟化酶,使肾上腺甾体激素生成减少,达到该作用的标准剂量为1000mg/d.另外,AG也抑制芳香化酶,使外周组织中由雄激素转化生成的雌激素减少.实验表明对AG较敏感的外周芳香化作用是AG的主要作用部位,以较低剂量即可产生疗效,且易耐受.本研究按1000mg/d和500mg/d的剂量分为两组,不予补充氢化可的松,旨在测定AG和它的主要
Aminoglutamate (AG) is an effective drug for hormone therapy in postmenopausal women with metastatic breast cancer. AG inhibits cholesterol side-chain lyase and C-21, C-11 and C-18 steroid hydroxylases and renders adrenal steroids Hormone production reduced to achieve the effect of the standard dose of 1000mg / d.In addition, AG also inhibit the aromatase, the peripheral tissues by estrogen-induced estrogen reduction experiments have shown that AG sensitive to peripheral aroma is AG Of the main role of the site, with a lower dose can produce efficacy, and easy to tolerate.This study at 1000mg / d and 500mg / d dose divided into two groups, not to add hydrocortisone, designed to determine the AG and it Mian