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细胞因子信号转导抑制因子 (SOCS)是一类存在于细胞中 ,对细胞因子具有负反馈调节作用的蛋白质因子 ,它能抑制胞内多种信号的转导。脂多糖 (LPS)是革兰氏阴性细菌胞膜外层的主要成分 ,它可促进单核细胞、巨噬细胞及上皮细胞等靶细胞合成和分泌细胞因子和炎性介质 ,使机体产生多种病变甚至败血性休克。SOCS可抑制STAT1丝氨酸和酪氨酸的磷酸化及NF κB活性 ,从而阻断LPS的信号转导 ,并能降低机体对LPS的敏感性和增加机体对LPS的耐受性。
Cytokine signal transduction inhibitory factor (SOCS) is a class of present in the cell, the negative feedback regulation of cytokines protein factor, it can inhibit the intracellular signal transduction. Lipopolysaccharide (LPS) is the main component of the outer layer of gram-negative bacterial membrane, which can promote the synthesis and secretion of cytokines and inflammatory mediators in target cells such as monocytes, macrophages and epithelial cells, Lesions and even septic shock. SOCS can inhibit the phosphorylation of STAT1 serine and tyrosine and NFκB activity, thus blocking the signal transduction of LPS, and can reduce the body’s sensitivity to LPS and increase the body’s tolerance to LPS.