论文部分内容阅读
应用琼脂稀释法对１１４株临床分离ＧＡＳ菌株的抗生素ＭＩＣ测定，和１０种抗生素对ＧＡＳ的抑菌作用，发现ＧＡＳ分离株仍对青霉素类抗生素敏感，其ＭＩＣ在０．００６２５～０．４ｍｇ／Ｌ之间；ＭＩＣ５０为０．０１２５～０．０５ｍｇ／Ｌ，其中青霉素最好；ＧＡＳ对头孢菌素类抗生素较敏感，其ＭＩＣ值在０．００３１２５～０．８ｍｇ／Ｌ范围内，ＭＩＣ５０为０．００６２５～０．４ｍｇ／Ｌ之间，头孢肟钠的抑菌效果尤为突出，而红霉素耐药菌株明显增多，６６．７％的菌株对红霉素耐药。这一结果提示：对ＧＡＳ感染病例，青霉素、氨苄霉素等抗生素仍可作为首选药物，对青霉素过敏或耐药的病例，主张使用头孢菌素类抗生素为宜，呼吁限制红霉素的使用。
The agar dilution method was used to determine the MICs of antibiotics in 114 clinically isolated GAS strains and the antibacterial activity of 10 antibiotics on GAS. The GAS isolates were still sensitive to penicillin antibiotics with MICs ranging from 0.00625 to 0.4 mg / L ; MIC50 is 0.0125 ~ 0.05mg / L, of which penicillin is the best; GAS is more sensitive to cephalosporins antibiotics, the MIC value in the range of 0.003125 ~ 0.8mg / L, MIC50 is 0. Between 00625 and 0.4 mg / L, the antibacterial effect of cefotaxime sodium was particularly prominent, while the erythromycin resistant strains were significantly increased, 66.7% of the strains were resistant to erythromycin. The results suggest that cases of GAS infection, penicillin, ampicillin and other antibiotics can still be the drug of choice, allergic to penicillin or resistant cases, advocating the use of cephalosporins antibiotics is appropriate, called for limiting the use of erythromycin.