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目的探讨偏头痛与缺血性卒中风险的相关性。设计系统性回顾和汇总分析。数据源检索Medline和Embase1966年至2004年6月公开发表的观察性研究,探讨偏头痛和缺血性卒中风险的关系。结果确定了14个研究(11个病例对照研究,3个大样本研究)。研究表明偏头痛患者发生卒中的风险增加(相对风险2.16,95%可信区间为1.89～2.48)。这种风险增加在有先兆的偏头痛患者(2.88,1.89～4.39)和无先兆的偏头痛患者(1.56,1.03～2.36)及服用口服避孕药者(8.72,5.05～15.05)中是一致的。结论观察性研究的资料显示偏头痛可能是卒中发生的一个危险因素。需要更多的研究去探讨其可能的机制。另外,需要进一步研究服用口服避孕药的偏头痛患者的卒中风险。
Objective To investigate the correlation between migraine and ischemic stroke risk. Design systematic review and summary analysis. DATA SOURCES Retrieval Medline and Embase An observational study published between the years of 6666 and June 2004 to investigate the relationship between migraine and ischemic stroke risk. The results identified 14 studies (11 case-control studies and 3 large sample studies). Studies have shown an increased risk of stroke in migraineurs (relative risk 2.16, 95% confidence interval 1.89 to 2.48). This risk increase was consistent with migraine headaches (2.88, 1.89 to 4.39) and migraine without aura (1.56, 1.03 to 2.36) and with oral contraceptives (8.72, 5.05 to 15.05). Conclusions Observational data suggest that migraine may be a risk factor for stroke. More research is needed to explore its possible mechanisms. In addition, there is a need to further investigate the risk of stroke in migraine sufferers taking oral contraceptives.