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目的:探究血清水通道蛋白4(AQP-4)与急性期视神经脊髓炎(NOM)患者临床特征的相关性,为临床上预防急性期NOM患者提供参考。方法:选取2009年1月至2016年1月来我院治疗的63例NOM患者,另选取20例健康体检者为对照,采用酶联免疫吸附试验测定所有受试者血清中AQP-4抗体浓度,分析AQP-4抗体水平与NOM患者临床特征的关系。结果:NOM患者血清AQP-4抗体的浓度为(425.45±18.34)ng/ml,阳性检出率为80.73%。健康体检者血清AQP-4抗体的浓度为(112.34±15.27)ng/ml。Spearman相关性分析发现,血清AQP-4抗体水平与EDSS评分、大脑磁共振成像病灶数及脊髓受累节段数均呈正相关(r=0.383,P=0.001;r=0.315,P=0.007;r=0.297,P=0.012);与至下一次复发间隔时间之间无明显相关性(r=-0.096,P=0.332)。结论:AQP-4抗体水平与NOM疾患者临床症状以及病程严重程度有一定的相关性,但AQP-4作为预测疾病复发的检测蛋白意义不大。
Objective: To investigate the correlation between serum AQP-4 and clinical features of acute neuromyelitis (NOM) in patients with NOM. Methods: Sixty-three patients with NOM who were treated in our hospital from January 2009 to January 2016 were enrolled in this study. Twenty healthy controls were selected as controls. Serum AQP-4 antibody concentrations were measured by enzyme-linked immunosorbent assay , Analysis of the relationship between AQP-4 antibody levels and clinical features of patients with NOM. Results: The serum AQP-4 antibody level in NOM patients was (425.45 ± 18.34) ng / ml, the positive rate was 80.73%. The concentration of serum AQP-4 antibody in healthy subjects was (112.34 ± 15.27) ng / ml. Spearman correlation analysis showed that the level of serum AQP-4 antibody was positively correlated with the EDSS score, the number of brain magnetic resonance imaging lesions and the number of spinal involvement segments (r = 0.383, P = 0.001; r = 0.315, P = 0.007; r = 0.297 , P = 0.012). There was no significant correlation with the interval of the next recurrence (r = -0.096, P = 0.332). CONCLUSIONS: The level of AQP-4 antibody is correlated with clinical symptoms and severity of disease in patients with NOM. However, AQP-4 is of little significance as a test protein for predicting the relapse of disease.