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目的研究Ｈｐ感染与胃癌及癌前病变中ｃｍｙｃ，ｐ２１，ｐ５３增殖细胞核抗原（ＰＣＮＡ）表达的相互关系，以探讨Ｈｐ可能的致癌机制．方法经内镜和病理诊断明确的病变者共１２０例，包括慢性浅表性胃炎（ＣＳＧ）、肠上皮化生、不典型增生、胃癌各３０例．以ＡＢＣ免疫组化法检测上述标本中ｃｍｙｃ，ｐ２１，ｐ５３，ＰＣＮＡ的表达，以改良Ｇｉｅｍｓａ法检测Ｈｐ．各组比较用χ２检验．结果肠型胃癌Ｈｐ阳性率为８３３％（２０／２４），弥漫型６例中Ｈｐ阳性１例．非贲门部胃癌阳性率为７３９％（１７／２３），贲门癌７例中阳性３例．胃癌Ｈｐ阳性率（６６７％）与ＣＳＧ（３３３％）比较差异非常显著（Ｐ＜００１）．各组Ｈｐ阳性的ｃｍｙｃ，ｐ２１，ｐ５３，ＰＣＮＡ与其Ｈｐ阴性者作相应比较均有显著或非常显著性差异（Ｐ＜００５～００１）．结论Ｈｐ感染与肠型胃癌的关系更密切，更容易发生于非贲门部．Ｈｐ感染可增加细胞的增殖活性，并通过使抑癌基因失活及癌基因激活而引起胃癌
Objective To study the relationship between Hp infection and the expression of cmyc, p21, and p53 proliferating cell nuclear antigen (PCNA) in gastric cancer and precancerous lesions in order to explore the possible carcinogenic mechanism of Hp. Methods Endoscopic and pathological diagnosis of a total of 120 cases of a total of 120 cases, including chronic superficial gastritis (CSG), intestinal metaplasia, atypical hyperplasia, 30 cases of gastric cancer. The expression of cmyc, p21, p53, and PCNA was detected by ABC immunohistochemical method. The modified Giemsa method was used to detect Hp. Each group was compared with χ2 test. Results The positive rate of Helicobacter pylori was 833% (20/24) in intestinal type gastric cancer, and Hp-positive one case was diffuse in 6 cases. The positive rate of non-cardia gastric cancer was 73.9% (17/23). There were 3 cases of cardiac cancer in 7 cases. The positive rate of Hp in gastric cancer (66.7%) was significantly different from that of CSG (33. 3%) (P<001). Hp-positive c-myc, p21, p53, PCNA were negatively correlated with their Hp-negative individuals. There was significant or very significant difference between each group (P<005～001). Conclusion Hp infection is more closely related to intestinal type gastric cancer, and it is more likely to occur in non-cardia spp. Hp infection increases cell proliferation activity and causes gastric cancer by inactivating tumor suppressor genes and activating oncogenes.