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采用ELISA方法，检测了36例急性白血病患者和42例恶性肿瘤患者化疗前后血清G－CSF水平，结果显示：两组化疗后血清G－CSF检出率分别为52％和33.3％，与化疗前比较无显著差异．而两组病程中合并感染者，检出率高达87.5％和77.6％，显著高于无感染组（P＜0．005）。Spearman等级相关分析，急性白血病合并感染血清G－CSF水平与白细胞总数呈负相关。恶性肿瘤仅于化疗后合并感染时，血清G-CSF水平与外周血白细胞总数呈负相关。并初步探讨了血清G－CSF变化的临床意义。
The serum G-CSF levels in 36 patients with acute leukemia and 42 patients with malignant tumors before and after chemotherapy were detected by ELISA. The results showed that the detection rate of serum G-CSF after chemotherapy was 52% and 33.3%, respectively, before chemotherapy There is no significant difference. In the two groups, the rate of detection was 87.5% and 77.6%, respectively, which were significantly higher than those without infection (P<0.005). According to the Spearman rank correlation analysis, the serum G-CSF level in acute leukemia co-infection was negatively correlated with the total number of white blood cells. Malignant tumors were only associated with infection after chemotherapy. Serum G-CSF levels were negatively correlated with the total number of white blood cells in peripheral blood. The clinical significance of serum G-CSF changes was discussed.