论文部分内容阅读
过敏性紫癜肾炎可以导致小儿慢性肾功能衰竭(CRF)和末期肾脏病(ESRD)。临床表现如肾炎综合症或肾病综合症,以及肾活检肾小球的改变,已用于预测转归。然而预测并不完全令人满意,因为某些只有轻微临床表现的患者发生肾功能不全,而有些严重肾脏损害。肾活检有明显改变的患者却完全恢复。作者回顾21例紫癜性肾炎,以确定怎样准确以临床过程和肾活检来预测最终肾脏功能。特别注意到了蛋白尿的严重程度和肾活检肾小球改变与肾功能的关系。材料和方法:21例紫癜性肾炎取自多伦多儿童医院1960—198d年做过肾活枪并至少随访18个月的住院病历。记录发病,30天—90天,9—15个月及最后一次随访或发生CRF或ESRD时肾脏状况,分为(1)蛋白尿和(或)血尿;(2)肾病综合症;(3)肾炎综合症;(4)肾功能衰竭。肾活检肾小球改变按国
Henoch-Schonlein purpura nephritis can cause childhood chronic renal failure (CRF) and end-stage renal disease (ESRD). Clinical manifestations such as nephritic syndrome or nephrotic syndrome, as well as renal biopsy glomerular changes, have been used to predict outcomes. However, the prediction is not entirely satisfactory, as some patients with mild clinical manifestations experience renal insufficiency with some severe kidney damage. Patients who had a significant change in their renal biopsy recovered completely. The authors reviewed 21 patients with purpuric nephritis to determine exactly how to predict the final renal function with clinical course and renal biopsy. Special attention was paid to the severity of proteinuria and renal biopsy glomerular changes associated with renal function. MATERIALS AND METHODS: Twenty-one cases of purpuric nephritis were obtained from hospitalized children in Toronto Children’s Hospital during the 1960-198d period with at least 18-month follow-up visits. (1) proteinuria and / or hematuria; (2) nephrotic syndrome; (3) nephrotic syndrome; and (3) Nephritic syndrome; (4) renal failure. Renal biopsy glomerular changes by country