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目的对2007年广东省珠海市登革热病例进行临床表现和流行病学特征分析。方法收集2007年8～10月间中山大学附属第五医院收治珠海市的125例登革热住院患者的流行病学和临床资料进行统计分析。结果发病年龄以20～39岁年龄组最多,发病高峰在9月上旬,主要爆发点1个,共有病例75例,占全部病例的60.0%。主要临床表现为发热(100.0%)、头痛(56.0%)、头晕(91.2%)、全身肌痛(63.2%)、疲乏(74.4%)、食欲减退(73.6%)、皮疹(68.8%)。实验室检查提示白细胞减少和血小板减少,分别占94.4%和93.6%,肝功能和心脏损害较明显。基因序列分析表明,此次流行主要为登革1型病毒。结论珠海市2007年流行的DF为登革1型病毒所致,病例符合典型DF的临床表现。经及时诊断和治疗,患者预后较好。
Objective To analyze the clinical manifestations and epidemiological characteristics of dengue fever in Zhuhai, Guangdong Province in 2007. Methods The epidemiological and clinical data of 125 cases of dengue inpatients admitted to the Fifth Affiliated Hospital of Sun Yat-sen University from August to October 2007 were collected for statistical analysis. Results The age of onset was the highest in the age group of 20-39 years. The peak incidence peak was in early September and the main outbreak point was 1. The total number of cases was 75, accounting for 60.0% of the total cases. The main clinical manifestations were fever (100.0%), headache (56.0%), dizziness (91.2%), myalgia (63.2%), fatigue (74.4%), loss of appetite (73.6%) and rash (68.8%). Laboratory tests prompted leukopenia and thrombocytopenia, accounting for 94.4% and 93.6%, liver function and heart damage more obvious. Sequence analysis showed that the epidemic was mainly dengue virus type 1. Conclusion Zhuhai epidemic of DF in 2007 due to Dengue virus type 1, the case of the clinical manifestations of typical DF. After timely diagnosis and treatment, patients with better prognosis.