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目的 :综合评价HBV宫内传播发生的危险因素 .方法 :应用Meta分析的固定效应和随机效应模型 ,针对 6篇有关HBV宫内传播危险因素的病例对照研究进行综合分析 ,共累计病例 2 93例 ,对照 1 30 3例 .结果 :孕妇HBVDNA阳性、HBeAg阳性、先兆早产、先兆流产、Apgar低分、剖宫产等 6个研究因素的合并OR值分别为 1 5 7.5 9(1 7.6 4～ 1 4 0 8.1 0 )、1 4 .0 1(7.1 0～ 2 4 .1 6 )、4 .6 3(1 .33～ 1 6 .0 9)、0 .73(0 .2 6～ 2 .0 1 )、1 .1 8(0 .39～ 3.5 6 )、1 .0 1 (0 .5 9～ 1 .75 ) .结论 :孕妇HBVDNA阳性、HBeAg阳性是宫内感染发生的高危因素 ;先兆早产与宫内感染的发生呈中等程度相关 ;先兆流产、Apgar低分、剖宫产与宫内感染的发生关联相对不明显 ,作用尚不能肯定
Objective: To evaluate the risk factors of intrauterine HBV intrauterine transmission.Methods: A total of 6 93 cases of intrauterine HBV intrauterine transmission were analyzed comprehensively by using the fixed effect and random effect model of Meta analysis. , Control 1,303 cases.Results: The combined OR of 6 research factors such as HBVDNA positive, HBeAg positive, threatened preterm birth, threatened abortion, Apgar low score, cesarean section were 15 59.5 (7.66-1 4 0 8.1 0), 1 4 .0 1 (7.1 0 ~ 2 4 .1 6), 4 .6 3 (1 .33 ~ 1 6 .0 9), 0 .73 (0 .26 ~ 2 .0 1), 1.1 8 (0 .39 ~ 3.56) and 1 .0 1 (0 .59 ~ 1 .75) .Conclusion: HBVDNA positive and HBeAg positive in pregnant women are the risk factors of intrauterine infection. And the occurrence of intrauterine infection was moderately related; threatened abortion, Apgar low score, cesarean section and intrauterine infection is relatively obvious, the role is not yet sure