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目的:探讨新疆地区汉族及维吾尔族非小细胞肺癌(NSCLC)患者EGFR突变发生率及差异。方法:采用ARMS法对54例汉族及50例维吾尔族非小细胞肺癌组织进行EGFR突变检测,并统计两组中EGFR突变民族差异性及相关因素差异。结果:维吾尔族非小细胞肺癌组中EGFR突变率为22.0%,汉族非小细胞肺癌组中EGFR突变率为40.7%,差异有统计学意义(P<0.05)。在EGFR突变中,均以19外显子缺失、21外显子L858R突变为主,且两者在两个民族所占比率比较无统计学差异。其他相关因素比较,如病理类型、吸烟情况与性别,两组均以腺癌、不吸烟、男性患者为主,无统计学差异(P>0.05)。结论:EGFR突变率在两个民族中存在差异,其余外显子突变情况及相关因素均无差异。
Objective: To investigate the incidence and the difference of EGFR mutations in Han and Uygur non-small cell lung cancer (NSCLC) patients in Xinjiang region. Methods: ARMS was used to detect EGFR mutation in 54 cases of Han and 50 cases of Uighur non-small cell lung cancer. The differences of nationalities and related factors of EGFR mutation in both groups were also statistically analyzed. Results: The frequency of EGFR mutation was 22.0% in Uyghur non-small cell lung cancer group and 40.7% in Han NSCLC group (P <0.05). In the EGFR mutation, the exon 19 deletion and the exon 21 L858R mutation were the main types, and the proportions of the two populations in the two ethnic groups were not statistically different. Other related factors, such as pathological type, smoking status and gender, the two groups were mainly adenocarcinoma, no smoking, male patients, with no significant difference (P> 0.05). Conclusion: There is a difference in EGFR mutation rate between the two ethnic groups. There is no difference in the other exon mutations and related factors.