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在２５±０．１℃，Ｉ＝０．１ｍｏｌ·ｄｍ－３ＫＮＯ３条件下，８０％（ｖ／ｖ）ＤＭＳＯ—Ｈ２Ｏ混合溶剂中，应用ｐＨ法测定了甘氨酸，Ｌ一缬氨酸，Ｌ－异亮氨酸，Ｌ－脯氨酸，Ｌ－丝氨酸，ＤＬ－苯丙氨酸等六种α－氨基酸（缩写为α－ＡＡ，记为Ｂ配体）的酸离解常数，铜（Ⅱ）－α－氨基酸．锌（Ⅱ）－α－氨基酸二元配合物的稳定常数及铜（Ⅱ）－芬布芬－α－氨基酸（芬布芬缩写为Ｆｅｎ，记为Ａ配体）和锌（Ⅱ）－芬布芬－α－氨基酸三元配合物的稳定常数．实验发现，在下面三对参数之间，即ｌｏｇβ１０２与ｐＫ，ｌＯｇβ１１１；与ｐＫ及１０ｇβ１１１与ｌｏｇβ１０２，均存在良好的直线自由能关系．用△ｌｏｇＫＭ和△ｌｏｇβ１１１两个参量描述了三元配合物相对于母体二元配合物的稳定性．讨论了溶剂的性质，配合物分子内配体之间的疏水作用，芳环之间的堆积作用对配合物稳定性的影响．
The contents of glycine, L-valine and L-iso-L-valine were measured by pH method in a mixed solvent of 80% (v / v) DMSO- The acid dissociation constants of six α-amino acids (abbreviated as α-AA, denoted as B ligand) such as leucine, L-proline, L-serine and DL-phenylalanine, - Amino acids. The stability constants of copper (Ⅱ) -fenbufen-α-amino acids (fenbufen abbreviated to Fen, denoted as A ligand) and zinc (Ⅱ) Finn-a-amino acid ternary complex stability constants. The experiment found that in the following three pairs of parameters, namely logβ102 and pK, lOgβ111; and pK and 10gβ111 and logβ102, there is a good linear free energy relationship. The stability of the ternary complex relative to the parent binary complex was described by using two parameters, △ logKM and △ logβ111. The properties of the solvent, the hydrophobic interaction between the ligands in the complexes and the stacking effect between the aromatic rings on the stability of the complexes were discussed.