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In the present paper, the therapeutic effect of acupuncture in treatment of 42 cases of epigastralgia was observed using multiple objective indexes, including electrogastrogram (EGG), output of gastric acid and pepsase, plasma prostaglandin (PG) E and gastrin contents, the number and morphological structure of gastrin (G) cells of the antrum mucosa. These 42 cases included 18 cases of deficiency syndrome type, 13 excess syndrome type and 11 mixed type of deficiency and excess. Zhongwan (CV 12), Neiguan (PC 6) and Zusanli (ST 36) were punctured combined with other acupoints according to syndrome patterns. After treatment, 32 cases (76.19%) were cured, 6(14.29%) had remarkable improvement and 4 (9.52%) had improvement, with a cure plus markedly effective rate of 90.48%. Gastroscopic and EGG examination suggested that the function and structure of the stomach returned to normal after acupuncture. In addition, acupuncture stimulation had a bi directional regulative action on gastric acid secretion, gastrin content, EGG activity, etc. Conclusion: Acupuncture treatment has a good regulative action on gastric function and structure in epigastralgia patients.