【摘 要】
：
Eight novel 1,4-disubstituted phthalazines(7-14)were designed and synthesized.The structures of all the synthesized compounds were confirmed by IR,~1H NMR,~(13)
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Eight novel 1,4-disubstituted phthalazines(7-14)were designed and synthesized.The structures of all the synthesized compounds were confirmed by IR,~1H NMR,~(13)C NMR,MS and elemental analysis.Their in vitro cytotoxicity against cancer cell lines(Bel-7402 and HT-1080)were evaluated by standard MTT assay.Among them,compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin.
Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the compounds were confirmed by IR, ~ 1H NMR, ~ (13) C NMR, MS and elemental analysis. against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Amm them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin.
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