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目的:调查研究沂水县药品不良反应(adverse drug reaction,ADR)发生概况,探讨ADR的发生规律,以期指导临床合理用药。方法:采用回顾性分析方法,分别从患者年龄、性别、上报ADR人员身份、给药途径、ADR涉及的药物种类以及ADR的临床表现等方面,用Excel 2003软件对沂水县1 585例ADR报告信息进行汇总、筛选、统计后展开分析研究。结果:ADR可发生于任何年龄组人群,男性多于女性,老人略高;ADR的报告主体是医疗机构,身份是医生;发生ADR的主要给药途径为静脉滴注;最常见的ADR临床表现是胃肠系统损害;引起ADR最多的是抗菌药物;中药注射剂出现新的ADR比例较高。结论:加强对ADR知识的宣传,警惕静脉给药风险,合理使用抗菌药物,慎重使用中药注射剂。
Objective: To investigate the incidence of adverse drug reactions (ADR) in Yishui County, and to explore the regularity of occurrence of ADR in order to guide clinical rational drug use. Methods: A retrospective analysis method was used to analyze the ADRs of Yishui County from 1 585 cases of Yishui County using Excel 2003 software in terms of patient’s age, sex, status of reporting ADR, route of administration, types of drugs involved in ADR, and clinical manifestations of ADR Information summary, screening, statistics, expand analysis and research. Results: ADR can occur in any age groups, more men than women, the elderly slightly higher; the main body of the ADR report is a medical institution, the identity of a doctor; ADR is the main route of administration for intravenous infusion; the most common ADR clinical manifestations Is the gastrointestinal system damage; ADR caused by the largest number of antimicrobial drugs; traditional Chinese medicine injection of a new high proportion of ADR. Conclusion: To strengthen the publicity of ADR knowledge, to be vigilant for the risk of intravenous administration, to use antimicrobial drugs reasonably and to use traditional Chinese medicine injection carefully.