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目的:研究Th1/Th2细胞因子在子痫前期的表达变化,并分析其与子痫前期之间的关系。方法:随机搜集2008年3月～2009年10月住院孕妇共60例,其中20例为正常妊娠妇女(对照组),40例为子痫前期患者(子痫前期组,轻度20例,重度20例),采用ELISA法检测孕妇外周静脉血清中细胞因子IFN-γ、IL-4水平。结果:轻度子痫前期组、重度子痫前期组IFN-γ表达水平高于对照组(P<0.01),重度子痫前期组IFN-γ表达水平高于轻度组(P<0.01);轻度子痫前期组、重度子痫前期组IL-4表达水平低于对照组(P<0.01),重度子痫前期组IL-4表达水平低于轻度组(P<0.01)。IFN-γ与IL-4水平呈负相关(r=-0.74,P<0.05);IFN-γ与胎盘重量呈负相关(r=-0.58,P<0.05);IFN-γ与新生儿体重呈负相关(r=-0.83,P<0.05);IL-4与胎盘重量呈正相关(r=0.78,P<0.05);IL-4与新生儿体重呈正相关(r=0.63,P<0.05)。结论:Th1/Th2细胞因子失衡,可能与子痫前期的发生有关。
Objective: To investigate the expression of Th1 / Th2 cytokines in preeclampsia and to analyze the relationship between them and preeclampsia. Methods: A total of 60 inpatients were enrolled from March 2008 to October 2009, of whom 20 were normal pregnant women (control group) and 40 were preeclampsia patients (preeclampsia group, 20 mild and severe 20 cases). The levels of cytokines IFN-γ and IL-4 in peripheral blood serum of pregnant women were detected by ELISA. Results: The levels of IFN-γ in severe preeclampsia group and severe preeclampsia group were higher than those in control group (P <0.01). The levels of IFN-γ in severe preeclampsia group were higher than those in mild preeclampsia group (P <0.01). The expression of IL-4 in mild preeclampsia group and severe preeclampsia group was lower than that in control group (P <0.01), while IL-4 expression in severe preeclampsia group was lower than that in mild group (P <0.01). IFN-γ and IL-4 levels were negatively correlated (r = -0.74, P <0.05); IFN-γ was negatively correlated with placental weight (r = -0.58, (R = -0.83, P <0.05). There was a positive correlation between IL-4 and placental weight (r = 0.78, P <0.05). IL-4 was positively correlated with neonatal body weight (r = 0.63, P <0.05). Conclusion: The imbalance of Th1 / Th2 cytokines may be related to the occurrence of preeclampsia.