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目的 :探讨IL 1,IL 6 ,IFNγ与糖尿病的关系。方法 :用免疫放射法对 15例 1型糖尿病、6 3例 2型糖尿病患者及 2 0例正常人的血IL 1,IL 6及IFNγ进行测定。 6 3例 2型糖尿病中有 30例合并早期肾病及眼底病变。结果 :1型糖尿病组血IL 1高于正常组及 2型糖尿病组 [(31 14± 14 36 )pg/ml对 (2 1 37± 8 2 4)pg/ml及(2 3 15± 8 5 3)pg/ml,两者均P <0 0 5 ];血IL 6明显低于正常组及 2型糖尿病组 [(0 45± 0 2 1)ng/ml对 (0 95± 0 47)ng/ml及 (1 5 3± 0 0 7)ng/ml,P <0 0 5 ,P <0 0 1];1,2型糖尿病组血IFNγ均低于正常组 [(0 94± 0 6 5 )IU/ml及 (1 0 1± 0 6 1)IU/ml对 (1 6 4± 0 49)IU/ml,均P <0 0 1]。结论 :1型糖尿病胰岛 β细胞损伤与血IL 1,IL 6密切相关 ;1,2型糖尿病IFNγ水平均降低 ,其临床意义有待进一步探讨
Objective: To investigate the relationship between IL 1, IL 6, IFNγ and diabetes. Methods: The levels of IL 1, IL 6 and IFNγ in 15 cases of type 1 diabetes mellitus, 63 cases of type 2 diabetes mellitus and 20 cases of normal people were measured by immuno-radioimmunoassay. Sixty three cases of type 2 diabetes mellitus combined with early nephropathy and retinopathy. Results: The level of IL-1 in type 1 diabetic patients was significantly higher than that in normal subjects and type 2 diabetic patients (3114 ± 1436 pg / ml vs (2137 ± 824) pg / ml and (2315 ± 85 3) pg / ml, both P <0 05]; blood IL 6 was significantly lower than that of normal group and type 2 diabetic patients (0 45 ± 0 2 1) ng / ml vs 0 95 ± 0 47 / ml and (153 ± 0 0 7) ng / ml respectively, P <0.05, P <0.01); The blood IFNγ in type 1 diabetes group was lower than that in normal group [(0 94 ± 0 6 5 ) IU / ml and (1 0 1 ± 0 6 1) IU / ml vs (1 64 ± 0 49) IU / ml, all P 0 01). CONCLUSION: The islet β cell injury of type 1 diabetes is closely related to the levels of IL-1 and IL-6 in blood and the levels of IFN-γ in type 1 diabetes mellitus are lower, and its clinical significance needs to be further explored