论文部分内容阅读
目的评价铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡的临床疗效及安全性。方法 60例重型颅脑损伤应激性溃疡患者随机分为试验组28例和对照组32例。2组均实施常规对症治疗,给予脱水、激素等积极性治疗,维持电解质及酸碱平衡,并给予适当的营养支持。对照组静脉滴注兰索拉唑30 mg+0.9%氯化钠注射液100 m L,每日2次;试验组在对照组治疗的基础上加用铝镁加1.5 g(15 m L),鼻饲,每日3次,2组疗程均为7 d。观察2组患者临床疗效、胃酸变化及服药期间不良反应发生率。结果试验组总有效率为82.1%,对照组为71.8%,2组差异无统计学意义(P>0.05)。治疗后,2组患者胃酸p H值均较治疗前显著升高(P<0.05);治疗后6 h开始,试验组胃酸p H显著高于对照组(P<0.05)。2组用药期间未见明显不良反应。结论铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡可迅速升高患者胃酸p H值,临床疗效确切,无明显不良反应。
Objective To evaluate the clinical efficacy and safety of aluminum-magnesium combined with lansoprazole in the treatment of stress ulcer in severe craniocerebral injury. Methods Sixty patients with severe craniocerebral injury and stress ulcer were randomly divided into experimental group (n = 28) and control group (n = 32). Both groups were given routine symptomatic treatment, given dehydration, hormones and other aggressive treatment, maintain electrolyte and acid-base balance, and give appropriate nutritional support. In the control group, lansoprazole 30 mg + 0.9% sodium chloride injection 100 ml twice daily was used in the control group. The experimental group was treated with magnesium and magnesium plus 1.5 g (15 m L) Nasal feeding, 3 times a day, 2 groups of treatment are 7 d. The clinical efficacy, gastric acid changes and the incidence of adverse reactions in the two groups were observed. Results The total effective rate was 82.1% in the experimental group and 71.8% in the control group. There was no significant difference between the two groups (P> 0.05). After treatment, the levels of gastric acid p H in both groups were significantly higher than those before treatment (P <0.05). After 6 h, the levels of gastric acid p H in the experimental group were significantly higher than those in the control group (P <0.05). No significant adverse reactions were observed during the two groups. Conclusion Al-Mg combined with lansoprazole can significantly increase gastric pH in patients with severe craniocerebral injury induced by stress ulcer. The clinical curative effect is definite and there is no obvious adverse reaction.