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Ca2+从胞质中的快速转移,是心肌细胞有效舒缩所必需的生理过程,由心肌肌浆网钙泵(sarco-plasmic reticulum Ca2+ATPase,SERCA2a)完成这一生理变化,而受磷蛋白(phospholamban,PLB)是对SERCA2a直接发挥调节作用的钙调节蛋白。越来越多的证据显示,由SERCA2a和它的调控者——PLB调
The rapid transfer of Ca2 + from the cytoplasm is a physiological process necessary for effective contraction and relaxation of cardiomyocytes and this physiological change is accomplished by the cardiac sarcoplasmic reticulum Ca2 + ATPase (SERCA2a) phospholamban, PLB) is a calcium regulatory protein that directly regulates SERCA2a. There is growing evidence that SERCA2a and its regulator, PLB Tune