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目的分析大连市疑似预防接种异常反应(AEFI)监测资料,了解AEFI系统的运转情况。方法用描述性流行病学分析对大连市2013年的疑似预防接种异常反应监测数据进行分析和评价。结果 2013年,大连市共接种各类疫苗(不含卡介苗)1 327 322剂次,AEFI监测系统共报告AEFI病例61例,报告发生率为4.59/10万。全市各区市县均有AEFI病例报出。AEFI县覆盖率为100%。报告病例最多的地区是旅顺口区,共报告14例,其次是甘井子区和西岗区,分别为8例。全年各月份均有病例发生,7月和10月病例报告最多,为11例,其次为5月和12月,为8例。61例AEFI病例中,年龄为1月龄至6岁。全市无群体性AEFI发生。AEFI报告发生率最高为麻疹风疹联合减毒活疫苗。结论大连市AEFI监测系统运转良好,及时报告率与及时调查率较高,但需进一步改良疫苗生产工艺,以降低吸附无细胞百白破联合疫苗及麻疹类疫苗导致的不良反应发生率。
Objective To analyze the surveillance data of suspected AEFI in Dalian and understand the operation of AEFI system. Methods Descriptive epidemiological analysis was used to analyze and evaluate the 2013 surveillance data of suspected immunization in Dalian. Results In 2013, 1 327 322 doses of all kinds of vaccines (excluding BCG) were vaccinated in Dalian. The AEFI surveillance system reported a total of 61 AEFI cases, with a reported incidence of 4.59 / 100 000. The city districts and counties have reported AEFI cases. AEFI County coverage is 100%. The most reported cases were Lushunkou District, with a total of 14 cases reported, followed by Ganjingzi District and Xigang District, respectively, in 8 cases. Cases occurred in all months of the year, with the highest reported in July and October, 11 cases, followed by May and December, 8 cases. Among 61 AEFI cases, the age ranged from 1 month to 6 years. No group AEFI occurred in the whole city. AEFI report the highest incidence of measles rubella combined live attenuated vaccine. Conclusion The AEFI monitoring system in Dalian is in good condition with timely reporting rate and timely investigation rate. However, the vaccine production process needs to be further improved to reduce the incidence of adverse reactions caused by the combination of the conjugate vaccine without cell and the measles vaccine.