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随着抗菌素、激素、抗肿瘤药物等的广泛应用,全身霉菌病,包括白色念珠菌性脑膜脑炎日益常见。但后者常被忽视。因而贻误治疗,影响预后。作者最近于半年内遇到3例白色念珠菌性脑膜脑炎,2例于生前作出诊断,经抗霉菌治疗后均告痊愈.1例生前未作出诊断者死亡,尸检后方才确诊本病。作者通过3例患者的治疗经验并结合文献复习,提出:在病因学方面首先体质因素十分重要。免疫机能低下者易患本病,如早产的新生儿,有先天性免疫机能障碍的儿童或有获得性免疫机能低下的成人,包括恶性疾病患者。内分泌障碍也是不利因素,特别是糖尿病及妊娠。某些治疗的滥用也有关系如广谱抗菌素、肾上腺皮质激素、免疫抑制剂以及抗肿瘤药物等.某些抢救
With the widespread use of antibiotics, hormones, antineoplastic agents and the like, systemic mycosis, including C. albicans meningoencephalitis, is increasingly common. But the latter is often overlooked. Thus delaying the treatment, affecting the prognosis. The authors recently encountered three cases of Candida albicans meningoencephalitis within six months, two cases were diagnosed before their death, and recovered after antimycotic treatment.One case was diagnosed without any prior death and was diagnosed only after autopsy. Based on the experience of three patients and the review of the literature, the authors suggest that first of all the constitutional factors are important in the etiology. Those who are immunocompromised are predisposed to the disease, such as premature neonates, children with congenital immunodeficiency or adults with acquired immunodeficiency disorders, including those with malignant disease. Endocrine disorders are also unfavorable factors, especially diabetes and pregnancy. Some of the abuse of treatment is also related to such as broad-spectrum antibiotics, adrenal hormones, immunosuppressive agents and anti-cancer drugs, etc. Some rescue