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由于多发性硬化的发病原理可能是免疫机制,目前正在应用各种免疫抑制剂.本文试图阐明每组药物的有利及有害作用.应用ACTH或肾上腺皮质激素治疗多发性硬化,即使对急性复发有部分效果,而对预防慢性进展作用甚小.目前我们已经证实甲基强的松龙或ACTH较大的剂量“冲击”可降低脑脊液中的IgG.这种情况表明皮质醇能够改变神经系统内的免疫反应.我们有这样的印象即对复发应用ACTH,可能促使继发复发的产生.Kiber等发现当病人用大剂量或隔日皮质醇,当撤药时出现继发复发的问题.延长减药
Since the pathogenesis of multiple sclerosis may be an immunological mechanism, a variety of immunosuppressive agents are currently being used.This article attempts to elucidate the beneficial and detrimental effects of each group of drugs.Using ACTH or adrenocorticotropic hormone for the treatment of multiple sclerosis, even with some acute relapse Effect, and little effect on the prevention of chronic progression.We have now shown that larger doses of methylprednisolone or ACTH reduce the IgG in cerebrospinal fluid, a fact that suggests that cortisol alters the innervation of the nervous system Of the immune response.We have the impression that the application of recurrent ACTH, may promote the occurrence of secondary recurrence.Kiber found that when patients with high doses or the next day cortisol, when withdrawal occurred when secondary relapse.Deletion of drugs