论文部分内容阅读
近年来，我们采用放射免疫分析法对４６例年龄为１５个月至１４岁的隐睾儿童的血清ＦＳＨ、ＬＨ、ＰＲＬ、Ｔ和Ｅ２进行了测定，其中１３例在手术时采取外阴部皮肤、进行成纤维细胞培养后，以３Ｈ－Ｒ１８８１为配体，用完整细胞测定法测定雄激素受体的特异性结合量和每个细胞的雄激素受体量。研究结果：（１）隐睾儿童血清ＦＳＨ值升高可能与早期已存在的睾丸曲精小管损害有关，（２）血清Ｅ２显著增高是本组隐睾儿童垂体－性腺轴内分泌功能最突出的改变，（３）隐睾儿童的雄激素受体的特异性结合量和每个细胞的雄激素受体量与正常对照组无显著性差异。研究表明，隐睾儿童存在高雌激素血症，可能是隐睾发生的重要致病因素之一，而靶器官雄激素受体无明显改变，表明隐睾可能不属于雄激素不敏感症的范畴
In recent years, we measured the serum levels of FSH, LH, PRL, T and E2 in 46 children with cryptorchidism aged 15 months to 14 years by radioimmunoassay. Thirteen of them took genital skin during operation, After fibroblasts were cultured, the specific binding of androgen receptor and the amount of androgen receptor per cell were determined by whole cell assay using 3H-R1881 as a ligand. (2) Serum E2 was significantly increased in children with cryptococcal hypothalamic-gonad axis, the most prominent change in endocrine function , (3) The specific binding of androgen receptor in cryptorchid children and the amount of androgen receptor per cell were not significantly different from the normal control group. Studies have shown that there is a high estrogenmia in children with cryptorchidism may be one of the important pathogenesis of cryptorchidism, and the target organ androgen receptor no significant change, indicating that cryptorchidism may not belong to the category of androgen insensitivity