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将肾上腺髓质组织块植入同种拟震颤麻痹大鼠模型脑内,移植物成活并发挥功能,受体大鼠的不正常行为获得改善。应用诱发荧光组化技术(SPG 法)检查出植入的肾上腺髓质嗜铬细胞含儿茶酚胺。在成活的移植细胞中,有些仍保留典型的正常嗜铬细胞形态,而其他的却向着肾上腺素能神经元的形态变化,有的呈椭圆形甚或发出短粗的突起。应用荧光分光光度计分析受体脑组织各部的儿茶酚胺含量,移植区脑组织的多巴胺含量很高。移植物分泌的多巴胺不间断地弥散入纹状体,直接作用于多巴胺受体起作用。所谓“过量移植”比较常量移植更有效地校正动物的异常行为。本文结果对于将肾上腺髓质脑内移植术过渡到临床应用治疗震颤麻痹具有重要意义。
The adrenal medulla mass was implanted into the brains of the same kind of rats with paralyzed paralysis, the grafts survived and functioned, and the abnormal behavior of the recipient rats was improved. The induced adrenal medullary chromaffin cells containing catecholamines were examined using fluorescence-induced fluorescence (SPG method). Some of the surviving transplanted cells retained typical normal pheochromocytoma morphology, while others were morphologically adaxial adrenergic neurons, with some oval or even stubby projections. Fluorescence spectrophotometer was used to analyze the content of catecholamine in each part of the recipient brain tissue. The content of dopamine in the brain tissue of the transplant area was high. The dopamine secreted by the graft continuously diffuses into the striatum and acts directly on the dopamine receptor. The so-called “over-transplant” more constant transplant more effective correction of animal abnormal behavior. The results of this paper for the adrenal medulla transplantation in the brain to clinical application of tremor paralysis is of great significance.