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目的观察氯吡格雷与阿司匹林联用对急性脑梗死患者的血小板聚集和血液流变学的影响,探讨联合用药的安全性。方法选择62例急性脑梗死患者,分为联合用药组(氯吡格雷+阿司匹林)和阿司匹林组,予氯吡格雷50mg/d,阿司匹林100mg/d,疗程2周,对两组患者检测治疗前后血小板聚集率及血液流变学检查,观察用药安全性。结果联合用药组治疗后GMP140、全血粘度和血小板聚集率降低,明显优于阿司匹林组(P<0.05)。两组副作用发生率无统计学意义。结论氯吡格雷与阿司匹林联合治疗急性脑梗死,具有明显抑制血小板聚集和改善血液流变学的作用,副作用无增加。
Objective To observe the effect of clopidogrel combined with aspirin on platelet aggregation and hemorheology in patients with acute cerebral infarction and to explore the safety of combination therapy. Methods Sixty-two patients with acute cerebral infarction were divided into two groups: the combination group (clopidogrel plus aspirin) and aspirin group. The patients were given clopidogrel 50 mg / d and aspirin 100 mg / d for 2 weeks. The levels of platelet Aggregation rate and hemorheological examination, observation of drug safety. Results After treatment with GMP140, whole blood viscosity and platelet aggregation rate decreased significantly, which was significantly better than aspirin group (P <0.05). The incidence of side effects in both groups was not statistically significant. Conclusion Combined treatment of clopidogrel and aspirin in patients with acute cerebral infarction has obvious effect of inhibiting platelet aggregation and improving hemorheology without any increase of side effects.