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1960年Bartter等首次报告2例肾小球旁器增殖、低钾硷中毒、血压正常,然而血管紧张素Ⅱ浓度及醛固酮却增高的一种综合征。据认为其发病机理涉及近曲小管或远曲小管重吸收钠的缺陷,这种缺欠又引起慢性细胞外液减少,继发性醛固酮增多和失钾。近来认为前列腺素增多是本病的关键,建议用前列腺素合成酶抑制剂治疗。新近的资料又进而提出与前列腺素
In 1960, Bartter et al first reported 2 cases of proliferation of glomerular bypass, hypokalemia, normal blood pressure, but the concentration of angiotensin II and aldosterone were increased in a syndrome. It is thought that the pathogenesis involves the proximal tubule or distal tubule reabsorption of sodium deficiency, which in turn causes a decrease in chronic extracellular fluid, secondary aldosterone increases and loss of potassium. Recently, an increase of prostaglandin is the key to this disease, it is recommended to use prostaglandin synthase inhibitor treatment. New information is in turn presented with prostaglandins