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原发性肺动脉高压至今仍被认为是不治之症,往往持续恶化和在诊断后3年左右死亡。本文报道1例用氯甲苯噻嗪(diazoxide)治疗期间肺动脉压降至正常。患者31岁女性。12个月以来有劳累性呼吸困难,肺动脉压65/35mmHg,肺楔嵌压正常。用华法令抗凝治疗及口服氯甲苯噻嗪,剂量渐增至600 mg/d。治疗3个月后心导管示肺动脉压降为37/20 mmHg。治疗9个月后肺动脉高压临床征象消失。15个月后肺动脉压降至25/12mmHg,症状消失,此时停用氯甲
Primary pulmonary hypertension is still considered an incurable disease to date and tends to worsen and to die about 3 years after diagnosis. This article reports the pulmonary arterial pressure was normalized in 1 patient treated with diazoxide. Patient 31 years old female. 12 months have tired breathing difficulties, pulmonary artery pressure 65 / 35mmHg, pulmonary wedge pressure normal. With warfarin anticoagulant therapy and oral hydrochlorothiazide, the dose gradually increased to 600 mg / d. Cardiac catheterization showed a pulmonary artery pressure drop of 37/20 mmHg 3 months after treatment. Clinical signs of pulmonary hypertension disappeared after 9 months of treatment. Pulmonary artery pressure dropped to 25 / 12mmHg after 15 months and the symptoms disappeared. Chloroform was stopped