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目的:探讨肝硬化患者口服葡萄糖后肝门部门静脉血流量的变化率对评估肝硬化肝功能的意义。方法:60名受试者,30例为正常成人,30名为乙肝型肝硬化患者,均无糖尿病史。口服30％浓度250ml的葡萄糖溶液后,采用二维超声及脉冲多普勒分别于口服前,口服后10分钟、20分钟、30分钟、40分钟、50分钟、60分钟测量肝门部门静脉主干内径及最大血流速度,并计算出肝门部门静脉血流量及其与口服前肝门部血流量的比值。结果:正常成人及肝硬化患者在口服葡萄糖后,肝门部门静脉血流量均明显升高,其血流量均值均在口服葡萄糖后20分钟达最高,相应地此时间点(口服后20分钟)的门静脉血流量与口服前门静脉血流量的比值(PVFR20)最高;正常人组PVFR20=1.88,肝硬化组PVFR20=1.30,肝硬化组明显低于正常人组。结论:口服葡萄糖后PVFR20的值可以作为评估肝硬化患者肝功能的一项简易指标。
Objective: To investigate the significance of rate of change of hilar portal vein blood flow after oral glucose administration in patients with cirrhosis to evaluate liver function of liver cirrhosis. Methods: Sixty subjects, 30 normal adults and 30 hepatitis B cirrhotic patients, had no history of diabetes. Oral 30% concentration of 250ml of glucose solution, using two-dimensional ultrasound and pulsed Doppler before oral administration of oral 10 minutes, 20 minutes, 30 minutes, 40 minutes, 50 minutes, 60 minutes measured hepatic portal vein diameter And the maximum blood flow velocity, and calculated the hepatic portal vein blood flow and oral administration of the ratio of hepatic portal blood flow. Results: After oral administration of glucose, the hepatic portal vein blood flow was significantly increased in both normal adults and patients with cirrhosis. The mean blood flow reached the highest level at 20 minutes after oral glucose administration. Correspondingly, at this time point (20 minutes after oral administration) The ratio of portal vein blood flow to oral anterior portal vein blood flow (PVFR20) was the highest. PVFR20 was 1.88 in normal subjects and 1.30 in cirrhotic patients. The liver cirrhosis group was significantly lower than that in normal subjects. Conclusion: The value of PVFR20 after oral administration of glucose can be used as a simple index to evaluate the liver function of patients with cirrhosis.