论文部分内容阅读
[目的]应用多普勒超声观察热碘油栓塞阻断兔肝VX2肿瘤血供的效果及其对肝脏血流动力学指标的影响。[方法]30只载瘤兔,随机分为3组,分别采用37°C生理盐水(对照)、37°C碘油及60°C热碘油经兔肝动脉灌注治疗,1周后多普勒超声观察肿瘤血供、肝动脉最大血流速度(Vmax)、阻力指数(RI)、门静脉平均血流速度(V)、门静脉血管内径的变化。[结果]治疗前,所有病灶能量及彩色多普勒均可检测出瘤内及瘤周较丰富血流信号,治疗后显示60℃热碘油组瘤内及瘤周血流信号均明显减弱,部分消失。治疗后60℃热碘油组肝动脉血流速度与37℃碘油组比明显降低(P=0.004),与对照组比阻力指数增大(P=0.021),门静脉血流速度及内径与其他两组比无明显变化(P均>0.05);60℃热碘油组存活期41.0±3.0d与对照组31.5±3.0d相比有显著差异(P=0.006)。[结论]热碘油栓塞可更有效地阻断兔肝VX2肿瘤供血,延长荷瘤兔生存期。
[Objective] To observe the effect of heat-oil embolization blocking blood supply of rabbit hepatic VX2 tumor and its effect on hepatic hemodynamics by Doppler ultrasound. [Methods] Thirty tumor-bearing rabbits were randomly divided into three groups and treated with 37 ° C normal saline (control), 37 ° C lipiodol and 60 ° C thermal lipiodol, respectively. After 1 week, Tumor ultrasonography was performed to observe the change of tumor blood supply, Vmax, RI, mean portal vein velocity (V) and portal vein diameter. [Results] Before treatment, all the lesion energy and color Doppler were able to detect more abundant blood flow signal in the tumor and the tumor circumference. After treatment, the signal of the tumor and peritumoral blood flow in the heat-lipiodol group at 60 ℃ was significantly weakened, Partially disappeared. Compared with the control group, the hepatic artery blood flow velocity at 60 ℃ and the lipiodol group at 37 ℃ were significantly decreased (P = 0.021), and the portal vein velocity and diameter were significantly different from other groups There was no significant difference between the two groups (P> 0.05). The survival time at 60 ℃ in the thermal lipiodol group was 41.0 ± 3.0d compared with 31.5 ± 3.0d in the control group (P = 0.006). [Conclusion] The thermal oil embolization can block the blood supply of rabbit liver VX2 tumor more effectively and prolong the survival of tumor-bearing rabbits.