论文部分内容阅读
目的:分析不同孕周胎膜早破(PPROM)性早产妊娠结局及产前使用糖皮质激素干预对早产新生儿结局的影响。方法:对126例未足月PPROM病例的临床资料进行回顾分析,比较不同孕周PPROM及产前是否使用宫缩抑制剂、糖皮质激素干预治疗的各种早产儿结局。结果:<34孕周PPROM新生儿Apgar评分、呼吸窘迫综合征(RDS)、窒息发生率、死亡率均明显高于>34孕周PPROM者,差异有统计学意义(P<0.01)。<34孕周组PPROM的新生儿重度窒息发生率、RDS、死亡率在宫缩抑制剂、糖皮质激素干预组明显低于对照组,两组间差异有统计学意义(P<0.01)。结论:对于<34孕周的PPROM产前使用宫缩抑制剂、糖皮质激素促胎肺成熟及抗生素预防感染等干预,可延长孕龄,减少围产儿并发症,增加成活率。
OBJECTIVE: To analyze the effect of gestational premature rupture of membranes (PPROM) on the outcome of preterm labor and the effect of prenatal glucocorticoid intervention on the outcome of preterm newborn infants. Methods: The clinical data of 126 cases of incomplete PPROM were retrospectively analyzed. The results of PPROM in different gestational weeks and prenatal use of tocolytic and glucocorticoid intervention were compared. Results: The Apgar score, respiratory distress syndrome (RDS), asphyxia and mortality in PPROM newborns <34 gestational weeks were significantly higher than those in PPROM> 34 gestational weeks. The difference was statistically significant (P <0.01). <34 gestational weeks group PPROM neonatal severe asphyxia, RDS, mortality in tocolysis, glucocorticoid intervention group was significantly lower than the control group, the difference between the two groups was statistically significant (P <0.01). CONCLUSIONS: PPROM prenatal use of tocolytic agents, glucocorticoids for fetal lung maturation, and antibiotic prophylaxis for prenatal <34 gestational weeks may prolong gestational age, reduce perinatal complications and increase survival.