Studies on a New Usage of Hypophosphorous Acid-iodine System in N-C Bond Cleavage

• 出 处: Chinese Chemical Letters
• 发表日期: 2003年04期
• 关键词: iodine pyrimidine carbonyl acetic naphthyl cyclohexane chains alkyl afford subst

A mixture of hypophosphorous acid (H3PO2) and iodine in acetic acid can cleave the N-alkyl bond in a variety of N-1 substituted pyrimidine derivative in relatively high yields, without any damage to the amido bond in the non-nucleosides pyrimidine base skeleton.

A mixture of hypophosphorous acid (H3PO2) and iodine in acetic acid can cleave the N-alkyl bond in a variety of N-1 substituted pyrimidine derivative in relatively high yields, without any damage to the amido bond in the non-nucleosides pyrimidine base skeleton .