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目的 评价颌面部恶性肿瘤CT表现与微血管密度 (MVD)及增殖细胞核抗原 (PCNA)表达的关系。方法 3 7例颌面部恶性肿瘤术前均行螺旋CT扫描。采用免疫组化方法 ,测定病理标本的VIII因子及PCNA表达 ,统计学分析MVD和PCNA与CT表现间的相关性。结果 颌面部恶性肿瘤的CT表现中肿瘤边界、强化时期、增强程度及有无淋巴结转移与MVD明显相关 ,而肿瘤大小及密度与MVD则无明显关系 ;肿瘤大小、边界、密度、强化时期及增强程度与PCNA明显相关。结论 CT表现与肿瘤内MVD和PCNA有明显相关性 ,有助于对颌面部恶性肿瘤预后进行评价。
Objective To evaluate the relationship between CT findings and microvessel density (MVD) and PCNA expression in maxillofacial malignant tumors. Methods Thirty seven patients with maxillofacial malignant tumors underwent preoperative helical CT scan. Immunohistochemistry was used to determine the expression of factor VIII and PCNA in pathological specimens. The correlation between MVD, PCNA and CT findings was statistically analyzed. Results The CT features of maxillofacial malignant tumors were significantly correlated with the tumor border, enhancement period, degree of enhancement and lymph node metastasis, while the tumor size and density had no relationship with MVD. The tumor size, border, density, duration of enhancement and The degree of enhancement is significantly associated with PCNA. Conclusions The CT findings are obviously correlated with the MVD and PCNA in the tumor, which is helpful to evaluate the prognosis of maxillofacial malignant tumor.