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目的：揭示原发性肝癌患者的ＨＢＶ、ＨＣＶ感染与其癌发生之间的联系。方法：ＨＢＶ、ＨＣＶ的感染采用ＨＢｓＡｇ的多抗，ＨＣＶ核心抗原、ＮＳ３和ＮＳ５抗原的单抗及免疫组织化学诊断。结果：４６例肝癌患者ＨＢＶ、ＨＣＶ双重感染１４例，单独ＨＢＶ感染２０例，单独ＨＣＶ感染６例，无ＨＢＶ和ＨＣＶ感染６例。不同ＨＢＶ、ＨＣＶ感染状况的肝癌患者的主要症状和体征、实验室检查、癌细胞分化程度和小肝癌的发现率差异无显著性。而ＨＢＶ和ＨＣＶ均阳性组患者的癌旁肝硬化的阳性率为１００％，较单独ＨＣＶ阳性组差异有显著性（Ｐ＜０．０５）。结论：肝癌患者有其自身固有的肿瘤临床行为，而与ＨＢＶ和／或ＨＣＶ感染的关系并不明显，ＨＢＶ和ＨＣＶ的重叠感染能使肝癌病进展到肝硬化阶段的可能性增加。
Objective: To reveal the association between HBV and HCV infection and its carcinogenesis in patients with primary liver cancer. Methods: HBV and HCV infections were detected by using monoclonal antibody against HBsAg, HCV core antigen, NS3 and NS5 antigens and immunohistochemistry. RESULTS: Forty-six cases of hepatocellular carcinoma had double infections of HBV and HCV, 20 cases of HBV infection alone, 6 cases of HCV infection alone, and 6 cases of HBV and HCV infection. There were no significant differences in the main symptoms and signs, laboratory tests, differentiation of cancer cells, and the detection rate of small hepatocellular carcinoma in patients with different HBV and HCV infection status. The positive rate of paraneoplastic cirrhosis in patients with HBV and HCV positive group was 100%, which was significantly higher than that of HCV positive group alone (P<0.05). Conclusions: Patients with liver cancer have their own inherent clinical behavior of the tumor, and the relationship with HBV and/or HCV infection is not obvious. The overlapping infection of HBV and HCV can increase the likelihood of progression of liver cancer to cirrhosis stage.